Detalles de la búsqueda
1.
Mechanisms of action and resistance in histone methylation-targeted therapy.
Nature
; 627(8002): 221-228, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38383791
2.
Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.
Bioorg Med Chem Lett
; 98: 129575, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38065292
3.
Flexibility and Cell Permeability of Cyclic Ras-Inhibitor Peptides Revealed by the Coupled Nosé-Hoover Equation.
J Chem Inf Model
; 61(4): 1921-1930, 2021 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33835817
4.
Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
Bioorg Med Chem Lett
; 30(20): 127475, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32781218
5.
Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor.
Cancer Sci
; 108(10): 2069-2078, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28741798
6.
Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator.
Bioorg Med Chem
; 25(13): 3540-3546, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28511909
7.
Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17.
Anticancer Drugs
; 23(1): 119-30, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22008853
8.
Discovery of imidazo[1,2-b]pyridazines as IKKß inhibitors. Part 2: improvement of potency in vitro and in vivo.
Bioorg Med Chem Lett
; 21(3): 904-8, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21232950
9.
Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating ß-Thalassemia and Sickle Cell Disease.
ACS Med Chem Lett
; 12(1): 121-128, 2021 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33488973
10.
Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.
Bioorg Med Chem Lett
; 20(17): 5113-8, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20675134
11.
Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
ACS Med Chem Lett
; 10(5): 737-742, 2019 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31097992
12.
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Acta Crystallogr F Struct Biol Commun
; 74(Pt 3): 156-160, 2018 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29497019
13.
Quantitative Structure-activity Relationship (QSAR) Models for Docking Score Correction.
Mol Inform
; 36(1-2)2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28001004
Resultados
1 -
13
de 13
1
Próxima >
>>